Pathways
Inflammatory Bowel Disease
Description:
The gastrointestinal (GI) tract plays a central role in maintaining immune homeostasis, i.e., tolerance to non-pathogenic commensal bacteria, self-antigens, and food antigens, while also protecting the host against pathogenic organisms by mounting an inflammatory response. The fine line between tolerance and inflammation of the GI immune system, when disrupted, may result in diseases such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disorder of the GI tract, it is defined into two major subtypes, Crohn&r...
References:
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Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad.
Scand J Gastroenterol. 2017 Nov;52(11):1185-1193. doi: 10.1080/00365521.2017.1349173. Epub 2017 Jul 12. Review. -
Immunopathogenesis of IBD: current state of the art.
Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27. doi: 10.1038/nrgastro.2015.186. Epub 2015 Dec 2. Review. -
The gut microbiota shapes intestinal immune responses during health and disease.
Nat Rev Immunol. 2009 May;9(5):313-23. doi: 10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600. -
Intestinal epithelial cells: regulators of barrier function and immune homeostasis.
Nat Rev Immunol. 2014 Mar;14(3):141-53. doi: 10.1038/nri3608. Review.
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